Cagliari Airport Airlines
| Airlines | Destinations |
|---|---|
| Air France | Seasonal: Paris–Charles de Gaulle |
| Air Malta | Malta |
| Austrian Airlines | Seasonal: Vienna |
| British Airways | London–Gatwick (begins 17 April 2022) |
| easyJet | Milan–Malpensa Seasonal: Basel/Mulhouse, Berlin, Geneva, London–Gatwick, Naples, Paris–Orly |
| Edelweiss Air | Seasonal: Zürich |
| Eurowings | Seasonal: Cologne/Bonn, Düsseldorf, Stuttgart |
| Iberia Express | Seasonal: Madrid |
| KLM | Seasonal: Amsterdam |
| Lufthansa | Seasonal: Frankfurt, Munich |
| Luxair | Seasonal: Luxembourg |
| Neos | Seasonal: Milan–Malpensa, Verona |
| Pobeda | Seasonal: Moscow–Vnukovo |
| Ryanair | Bari, Beauvais, Bergamo, Bologna, Brindisi, Budapest, Catania, Charleroi, Cuneo, Kraków, London–Stansted, Malta, Milan–Malpensa, Naples, Nuremberg, Palermo, Parma, Pisa, Porto, Rome–Ciampino, Seville, Trieste, Turin, Valencia, Verona Seasonal: Carcassonne (begins 2 May 2022), Dublin, Hahn, Karlsruhe/Baden-Baden, Madrid, Palma de Mallorca, Perugia, Poznań, Rimini, Venice, Vienna, Warsaw–Modlin, Weeze |
| SkyAlps | Seasonal: Bolzano (begins 29 May 2022) |
| S7 Airlines | Seasonal: Moscow–Domodedovo |
| Smartwings | Seasonal: Prague |
| Transavia | Seasonal: Paris–Orly |
| Volotea | Genoa, Milan Linate, Naples, Rome Fiumicino, Turin, Verona Seasonal: Ancona, Bilbao (begins 28 May 2022), Bordeaux, Hannover (begins 28 May 2022), Lille (begins 2 June 2022), Lyon, Marseille, Nantes, Nice (begins 30 May 2022), Pescara, Prague, Strasbourg, Toulouse, Venice |
| Vueling | Barcelona |
| Wizz Air | Milan–Malpensa, Venice |